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KMID : 1145120160140030317
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Asian Journal of Beauty and Cosmetology
2016 Volume.14 No. 3 p.317 ~ p.328
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Development of Whitening Cosmetic Ingredients from Cudrania tricuspidata Stem Extract
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Han Hyo-Sun
Kim Soo-Yeon
Lim Dae-Jin
Whang Wan-Kyunn
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Abstract
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Purpose: This study was conducted to investigate the possibility of Cudrania tricuspidata (C. tricuspidata) stem extract as whitening cosmetic material.
Methods: We performed TLC and HPLC analysis to investigate the anti-oxidant compounds and its contents in C. tricuspidata stem extract fractions (hexane, ethyl acetate, butanol, and water). In order to evaluate anti-oxidant effects, radical and superoxide scavenging activities were conducted by using DPPH, ABTS free radicals and xanthine oxidases, respectively. In addition, we examined tyrosinase activity and cellular melanin content to verify the whitening effects of C. tricuspidata stem extract.
Results: We found out that both ethyl acetate fraction and butanol fraction among the fractions of C. tricuspidata stem extract had anti-oxidant compounds. Our results pointed out that the active fractions have significant free radical and superoxide scavenging activities, and the fraction of ethyl acetate is the best. The ethyl acetate fraction (IC50 24.4 ppm) and butanol fraction (IC50 88.3 ppm) reduced tyrosinase activities and melanin content in a concentration-dependent manner.
Conclusion: Through the results, C. tricuspidata stem extract has the potent as a cosmetic material which possess the anti-oxidant and whitening effects.
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KEYWORD
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Cudrania tricuspidata, Anti-oxidant, Tyrosinase, Melanin, Whitening cosmetic
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